What administration strategy can help prevent complications related to uric acid nephropathy in a client receiving allopurinol and methotrexate?

The administration strategy that involves allopurinol and encouraging increased fluid intake is crucial in preventing complications related to uric acid nephropathy, especially in clients receiving allopurinol and methotrexate. Allopurinol is used to reduce uric acid levels in the body, which is important because high levels can lead to the formation of crystals in the kidneys and potentially result in nephropathy. Increasing fluid intake helps dilute the urine and promotes urination, which further assists in flushing out excess uric acid from the kidneys. This is key in preventing the crystallization of uric acid, thereby reducing the risk of damage to renal tissue.

Fluid intake is vital in managing urine output and maintaining renal perfusion, which can be compromised by high uric acid levels. By encouraging increased fluid intake, healthcare providers help ensure that the kidneys work effectively, and the risk of complications associated with uric acid nephropathy is minimized. This strategy is especially important for patients on medications like methotrexate, as they can have nephrotoxic effects if kidney function is not monitored and supported adequately.

In contrast, restricting fluid intake, as seen in some of the other options, would likely increase the risk of uric acid precipitation in the